Update your browser for a better shopping experience!

Get faster load times, stronger security and access to all features.

Dramatically Different Moisturizing Lotion+™ 125ml

Product code: T239120F

Dermatologist-developed silky, fast-absorbing moisturising lotion with pure urea rapidly strengthens the skin barrier. Dermatologist developed. Dermatologist tested. Non-comedogenic. Suitable for post-procedure skin. Allergy tested. 100% fragrance free.

Our daily urea moisturiser for face delivers hydration + soothing moisture for skin in need of comfort. Hydrates to soften and smooth. Helps strengthen skin’s own moisture barrier so more moisture stays in. Replenishes skin’s oil-water balance for healthy-looking skin. Silky lotion slips on easily, absorbs quickly. Appropriate for use as soon as 1 day post treatment. *Shown to be safe for use following a non-ablative laser treatment in a two-week clinical usage test.

Product details

Item details

Benefits: Strengthens skin’s moisture barrier for healthy looking skin.

Sunflower seed cake, barley extract and cucumber fruit extract help strengthen skin’s barrier, improve its resiliency, and balance and retain skin’s moisture levels

Skin Types: Very Dry to Dry, Dry Combination.

Key Ingredients: Natural moisturising factors, glycerin, urea, blend of barley, sunflower and cucumber.

Pure glycerin is a powerful humectant that supports your skin’s natural moisture barrier by attracting moisture from the air and retaining water in skin to help keep skin hydrated.

Pure urea is a humectant that occurs naturally in skin. It helps pull in water and bind moisture to skin to help keep it hydrated and balanced.

3 pro-lipids help support skin’s natural barrier.

Free Of: Fragrance, drying alcohol.

More information

How to Use: Spread all over face/throat twice daily, or where needed. For best results, use after facial soap and clarifying lotion.

Sunflower seed cake, barley extract, cucumber fruit extract

Product Size: 125 ml

Hypoallergenic: Yes

Fragrance Free: Yes

Dermatologically Tested: Yes

Product Texture: Gel

Clinique

Dramatically Different Moisturizing Lotion+™ 125ml

£37

£29.60 per 100ml

Also available in: Moisturising Gel and Moisturising Lotion
Free standard delivery over £75

Reviews (604)

4.2

60% Recommended this product

Mentions
19 June 2026jianjie
Verified Purchase

Useful and suits my skin

Yes, I recommend this

Use this product every day it suits my skin and keeps it moisturized. I wouldn't be without it.

Helpful?

06 June 2026Butterfly2021
Verified Purchase

Would recommend

Yes, I recommend this

Excellent for dry skin, easy to use and pump keeps it hygenic

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

29 May 2026Petally
Verified Purchase

Moisturiser

Yes, I recommend this

Nice moisturiser, not to thick and goes on easily. Makes your skin feel nice and smooth. Will definitely buy again.

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

14 May 2026Nicola

Changed formulation

Originally posted on Clinique UK

I have been using this moisturiser for decades but the last bottle seemed different. I persisted, then googled it and found that the recipe has changed. I don't like the feel of it - not light and fresh as it was before - and it seems to leave a plastic-feeling film on my skin. Will not be using it again.

Helpful?

01 May 2026Surann
Verified Purchase

Best moisturiser ever!

Yes, I recommend this

Clinique is my go to brand for skin care and I've used this moisturiser for many years. It's light texture leaves my skin feeling sort and silky and my foundation glides on after application.

Helpful?

26 April 2026ibelieveinangels
Verified Purchase

The best you can get

Yes, I recommend this

I have used this since 1970 .and highly recommend it .its not greasy and in my opinion the very best

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

24 April 2026Hiya21212131
Verified Purchase

Great value

Yes, I recommend this

Excellent great value..............................!!

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

17 April 2026George2011
Verified Purchase

Family buy

We all use this moisturiser, husband, teenage son and all the girls. Some of us have sensitive skin. This just suits for all of us. Gentle, has no strong oerfume

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

15 April 2026Little Welsh lady
Verified Purchase

Best bargain

Yes, I recommend this

I always get this moisturiser from m&s when it’s on sale.it lasts for ages best moisturiser I have had.

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

15 April 2026Betsy Anne
Verified Purchase

Special touch

Yes, I recommend this

Bought this when I had twenty percent off ,A friend had bought me this as a presents And I absolutely love it so soft on my skin it’s definitely a winner

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

07 April 2026Addingtonbelle

Brilliant stuff

Originally posted on Clinique UK

Love this amazing moisturizing lotion. Been using it for years. Try it for yourself. You won't be disappointed.

Helpful?

07 April 2026Wildflowerwendy

Daily gentle moisturiser

Originally posted on Clinique UK

I never miss using this on my aging skin. It keeps my skin soft, smooth and comfortable. I am sure it's responsible for keeping me almost wrinkle free.

Helpful?

02 April 2026Hobodobo
Verified Purchase

Best moisturiser ever

Yes, I recommend this

Love this product, have used for years, massages into skin perfectly leaving fresh, healthy looking skin

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

30 March 2026Pinny

Really feels like it's protecting my skin.

Originally posted on Clinique UK

Have used dramatically different moisturiser for more years than I care to reveal and I still use it at night but felt that I ought to use something with an spf fo during the day. This is the perfect solution and really feels protective.

Helpful?

30 March 2026Spider0282

Fabulous - will never not use it

Originally posted on Clinique UK

I have been using the Clinique 3-step routine since about 1980 and I love every bit of it - especially this moisturiser, which is light, easily absorbed and makes my skin feel lovely. I will continue using it for as long as they keep making it!

Helpful?

30 March 2026Shirley P

Fab moisturising lotion

Originally posted on Clinique UK

I love love love this moisturising lotion and wouldn't buy any other. Only given 4 stars as get so frustrated with how much is left in the bottle once the pump stops working and all the faff of trying to use what is left as it's too expensive to discard.

Helpful?

22 March 2026Melvin5
Verified Purchase

I have used the moisturising lotion before

Having used the cream for many years and could obtain it at a discount ordered a bottle immediately and am delighted that it has arrived

Helpful?

21 March 2026Gilf
Verified Purchase

Moisturiser

Yes, I recommend this

Good quality. Good value. I have used this product for 20years , my skin is smooth and wrinkle free

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

18 March 2026Mo4
Verified Purchase

Just right

Yes, I recommend this

Just the right amount of moisture in the lotion. As well just the right quantity when using the pump bottle.

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

17 March 2026Mgtb23
Verified Purchase

Long time favourite

Yes, I recommend this

Long time user, no surprises. Keeps my skin soft and supple

Reviewer Ratings

Quality

Excellent

Helpful?

Reviewer Ratings

Quality

Excellent

1 of 101